Long term methylphenidate exposure and growth in children and adolescents with ADHD. A systematic review and meta-analysis

Long term methylphenidate exposure and growth in children and adolescents with ADHD. A systematic review and meta-analysis

Authors
Carucci, S. Balia, C. Gagliano, A. Lampis, A. Buitelaar, J. K. Danckaerts, M. Dittmann, R. W. Garas, P. Hollis, C. Inglis, S. Konrad, K. Kovshoff, H. Liddle, E. B. McCarthy, S. Nagy, P. Panei, P. Romaniello, R. Usala, T. Wong, I. C. K. Banaschewski, T. Sonuga-Barke, E. Coghill, D. Zuddas, A. Adduce Consortium
Year
2021
Journal
Neuroscience & Biobehavioral Reviews
Volume
120
Pages
509-525
BACKGROUND Methylphenidate (MPH) is an efficacious treatment for ADHD but concerns have been raised about potential adverse effects of extended treatment on growth. OBJECTIVES To systematically review the literature, up to December 2018, conducting a meta-analysis of association of long-term (> six months) MPH exposure with height, weight and timing of puberty. RESULTS Eighteen studies (ADHD n = 4868) were included in the meta-analysis. MPH was associated with consistent statistically significant pre-post difference for both height (SMD = 0.27, 95% CI 0.16-0.38, p < 0.0001) and weight (SMD = 0.33, 95% CI 0.22-0.44, p < 0.0001) Z scores, with prominent impact on weight during the first 12 months and on height within the first 24-30 months. No significant effects of dose, formulation, age and drug-naive condition as clinical moderators were found. Data on timing of puberty are currently limited. CONCLUSIONS Long-term treatment with MPH can result in reduction in height and weight. However, effect sizes are small with possible minimal clinical impact. Long-term prospective studies may help to clarify the underlying biological drivers and specific mediators and moderators.

Oversett med Google Translate
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Type of intervention

Treatment and Child Welfare Interventions

Topic

Mental Health Problems and Disorders

ADHD

Intervention

Pharmacological Treatment

Stimulants

Age group

School Aged Children (6-12 years)

Adolescents (13-18 years)

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