Metaanalyse over randomiserte, kontrollerte forsøk for pediatrisk tvangslidelse

Meta-analysis of randomized, controlled treatment trials for pediatric obsessive-compulsive disorder

Authors
Watson, H. J. Rees, C. S.
Year
2008
Journal
Journal of Child Psychology & Psychiatry & Allied Disciplines
Volume
49
Pages
489-98
OBJECTIVE: To conduct a meta-analysis on randomized, controlled treatment trials of pediatric obsessive-compulsive disorder (OCD). METHOD: Studies were included if they employed randomized, controlled methodology and treated young people (19 years or under) with OCD. A comprehensive literature search identified 13 RCTs containing 10 pharmacotherapy to control comparisons (N = 1016) and five cognitive-behavioral therapy (CBT) to control comparisons (N = 161). RESULTS: Random effects modeling yielded statistically significant pooled effect size (ES) estimates for pharmacotherapy (ES = .48, 95% CI = .36 to .61, p < .00001) and CBT (ES = 1.45, 95% CI = .68 to 2.22, p = .002). The results were robust to publication bias. CONCLUSIONS: This is the first meta-analysis of treatment RCTs for pediatric OCD. CBT and pharmacotherapy were the only treatments effective beyond control in alleviating OCD symptoms. CBT showed a greater ES than pharmacotherapy. Previous meta-analyses that included uncontrolled trials exaggerated the efficacy of both treatments.

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Type of intervention

Treatment and Child Welfare Interventions

Topic

Mental Health Problems and Disorders

Anxiety Problems

Anxiety and Anxiousness

Obsessive Compulsive Disorder

Intervention

Psychological Treatments

Cognitive Behavioral Therapy, Behavioral Therapy and Cognitive Therapy

Pharmacological Treatment

Antidepressants

Sedatives

Age group

School Aged Children (6-12 years)

Adolescents (13-18 years)

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