This review aimed to analyze the effects of laughter-inducing therapy on anxiety, pain, and stress in children by synthesizing existing randomized controlled trials (RCTs). Researchers conducted a systematic literature review and meta-analysis, following the Cochrane Collaboration's methodology for systematic literature review and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We selected and evaluated 12 studies for quality using the Risk of Bias 2.0 tool. Seven studies were included in the meta-analysis, which showed that clown therapy produced a moderate effect on pain relief and a large effect on anxiety reduction in pediatric patients. In conclusion, this review highlights the potential of laughter-inducing therapies as an effective clinical intervention for reducing anxiety, pain, and stress in pediatric patients. These findings provide evidence supporting the use of laughter-based interventions as alternative or complementary approaches in medical settings. The review also underscores the need for further research across diverse clinical environments to validate the effectiveness of laughter-inducing therapies in broader pediatric populations. Overall, the incorporation of laughter-inducing therapy into clinical practice may play a valuable role in enhancing the overall well-being of pediatric patients.
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