Effekt av flerumettede fettsyrer som kosttilskudd under amming på nevrokognitiv utvikling hos premature barn fra spedbarn til skolealder: Systematisk oversikt og metaanalyse

The Effect of Supplementation of Long-Chain Polyunsaturated Fatty Acids during Lactation on Neurodevelopmental Outcomes of Preterm Infant from Infancy to School Age: A Systematic Review and Meta-analysis

Authors
Wang, Q. Cui, Q. Yan, C.
Year
2016
Journal
Pediatric Neurology
Volume
59
Pages
54-61
Background and objective Long-chain polyunsaturated fatty acids, especially docosahexaenoic acid, have been suggested as a nutrition factor affecting visual and neurobehavioral development of preterm infants. Several randomized controlled trials (RCTs) have investigated the effect of supplementation of long-chain polyunsaturated fatty acids on preterm infants. We conducted a systematic review and meta-analysis to examine the efficacy of long-chain polyunsaturated fatty acid supplementation of formula or breast milk on the neurodevelopment outcomes of preterm infants. Methods Two authors searched PubMed and Cochrane Library (CENTRAL) for RCTs assessing efficacy of long-chain polyunsaturated fatty acids supplementation on the neurobehavioral and development outcomes of preterm infant. Human RCTs which supplemented long-chain polyunsaturated fatty acids during lactation and assessed neurodevelopment were included. The quality of each RCT was assessed, and the results of eligible trials were included in the systematic review and meta-analysis. Results We included 11 RCTs with 2272 total participants. Methodologic limitations existed to some extent in most RCTs that were included. Because the age of the participants from different trails was not the same, different scales and indexes had been assessed from different RCTs. Our meta-analysis indicated a significant effect of long-chain polyunsaturated fatty acids supplementation on the neurodevelopment of preterm infants assessed by the Mental Development Index of the Bayley Scales at one to three years of age versus the control groups. Conclusion Analysis of our consolidated data indicates that long-chain fatty acid supplementation results in a significant improvement in the neurodevelopment of preterm infants as assessed by the Mental Development Index at one to three years of age. The available evidence suggests that long-chain polyunsaturated fatty acid supplementation during lactation may accelerate the pace of neurodevelopment in preterm infants, although their final developmental outcome may be unchanged. Copyright © 2016 Elsevier Inc.

Oversett med Google Translate
-
Type of intervention

Preventive- and Promotive Health Interventions

Topic

Development and Life Coping Skills

Cognition

Motor development

Language

Intervention

Alternative Treatment

Nutritional Supplements and Nutrition

Age group

Infants and Toddlers (0-2 years)

Preschool Aged Children (3-5 years)

School Aged Children (6-12 years)

More information
Looking for more information on this topic? Click on the links below to search PsykTestBarn and Håndboka