Systematisk oversikt og metaanalyse over medikamentell behandling av symptomer på ADHD hos barn med gjennomgripende utviklingsforstyrrelser

Systematic Review and Meta-analysis of Pharmacological Treatment of the Symptoms of Attention-Deficit/Hyperactivity Disorder in Children with Pervasive Developmental Disorders

Authors
Reichow, B. Volkmar, F. R. Bloch, M. H.
Year
2013
Journal
Journal of Autism and Developmental Disorders
Volume
43
Pages
2435-2441
Many children with pervasive developmental disorders (PDD) exhibit behaviors and symptoms of attention-deficit/hyperactivity disorder (ADHD). We sought to determine the relative efficacy of medications for treating ADHD symptoms in children with PDD by identifying all double-blind, randomized, placebo-controlled trials examining the efficacy of medications for treating ADHD symptoms in children with PDD. We located seven trials involving 225 children. A random effects meta-analysis of four methylphenidate trials showed methylphenidate to be effective for treating ADHD symptoms in children with PDD (ES = .67). Several adverse events were greater for children were taking methylphenidate compared to placebo. An individual trial of clonidine and two trials of atomoxetine suggest these agents may also be effective in treating ADHD symptoms in children with PDD.

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Type of intervention

Treatment and Child Welfare Interventions

Topic

Mental Health Problems and Disorders

ADHD

Intervention

Pharmacological Treatment

Sedatives

Stimulants

Age group

Preschool Aged Children (3-5 years)

School Aged Children (6-12 years)

Age not specified

More information
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