Non-pharmacological interventions for perinatal depression and anxiety among adolescent mothers: A systematic review and meta-analysis

Non-pharmacological interventions for perinatal depression and anxiety among adolescent mothers: A systematic review and meta-analysis

Authors
Mwita, M. Dewey, D. Konje, E. T. Patten, S.
Year
2025
Journal
Journal of Affective Disorders
Volume
379
Pages
168-175
Background: Perinatal depression and anxiety are the most common mental health disorders among pregnant and postpartum adolescents. Pharmacological and non-pharmacological interventions exist for perinatal depression and anxiety; however, there is limited evidence on the effectiveness of non-pharmacological interventions in adolescent mothers. Aim: To identify, evaluate, and summarize the available evidence on the effectiveness of non-pharmacological interventions for the prevention and treatment of perinatal depression and anxiety in adolescent mothers. Methods: We followed the Cochrane guidelines in conducting the reviews and the Preferred Reporting Items for Systematic review and Meta-Analysis (PRISMA) guidelines in reporting the findings. Randomized clinical trials (RCTs), interventional studies, cohort studies, and case-control studies of non-pharmacological interventions that assessed depression and/or anxiety symptoms or diagnoses after intervention in adolescent mothers were eligible for inclusion. We searched PubMed/Medline, Embase, Cochrane Central Register of Controlled Trials, and PsycINFO, as well as the reference lists of relevant studies and grey literature. Results: We identified eight clinical trials that were eligible for inclusion in the systematic review (n = 806); four of these studies were eligible for inclusion in a meta-analysis (n = 451). Non-pharmacological interventions (specifically Cognitive Behavioral Therapy (CBT) and Interpersonal Therapy (IPT)) for depressive symptoms showed small to moderate effects (SMD: -0.57, 95 % CI: -0.77, -0.36; p-value<0.001) in the intervention groups compared to the control groups. Conclusions: Non-pharmacological interventions, specifically CBT and IPT, may be effective in treating perinatal depression among adolescent mothers. These interventions could be successfully delivered by trained health care professionals in health care settings such as antenatal clinics.

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Type of intervention

Treatment and Child Welfare Interventions

Topic

Mental Health Problems and Disorders

Emotional Problems

Depression and Depressed Mood

Anxiety Problems

Anxiety and Anxiousness

Biological Risk Factors, Diseases and Symptoms

Pregnancy

Intervention

Psychological Treatments

Cognitive Behavioral Therapy, Behavioral Therapy and Cognitive Therapy

Psychodynamic/Interpersonal Therapy

Psychosocial Treatments

Counseling/Support

Age group

Adolescents (13-18 years)

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