Neurodevelopmental effects of prenatal vitamin D in humans: systematic review and meta-analysis

Neurodevelopmental effects of prenatal vitamin D in humans: systematic review and meta-analysis

Forfattere
Garcia-Serna, A. M. Morales, E.
Årstall
2020
Tidsskrift
Molecular Psychiatry
Volum
25
Sider
2468-2481
Diverse studies have investigated the impact of prenatal exposure to vitamin D levels on brain development; however, evidence in humans has never been systematically reviewed. This article summarized evidence of the association between 25-hydroxyvitamin D [25(OH)D] levels in maternal blood in pregnancy or newborn blood at birth and neurodevelopmental outcomes, including cognition, psychomotor performance, language development, behavioral difficulties, attention deficit and hyperactivity disorder (ADHD), and autistic traits. PubMed, Web of Science and SCOPUS databases were systematically searched for epidemiologic studies published through May 2018 using keywords. Random-effects meta-analyses were conducted. Of 260 identified articles, 25 were included in the present review. Comparing the highest vs. the lowest category of prenatal 25(OH)D levels, the pooled beta coefficients were 0.95 (95% CI -0.03, 1.93; p = 0.05) for cognition, and 0.88 (95% CI -0.18, 1.93; p = 0.10) for psychomotor development. The pooled relative risk for ADHD was 0.72 (95% CI, 0.59, 0.89; p = 0.002), and the pooled odds ratio for autism-related traits was 0.42 (95% CI, 0.25, 0.71; p = 0.001). There was little evidence for protective effects of high prenatal 25(OH)D for language development and behavior difficulties. This meta-analysis provides supporting evidence that increased prenatal exposure to 25(OH)D levels is associated with improved cognitive development and reduced risk of ADHD and autism-related traits later in life. Associations represent a potentially high public health burden given the current prevalence of vitamin D deficiency and insufficiency among childbearing aging and pregnant women. Copyright © 2019, Springer Nature Limited.

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Tiltaksnivå

Forebyggende og helsefremmende tiltak

Tema

Psykiske vansker og lidelser

Atferdsproblemer

Utagerende/utfordrende atferd (uro, bråk)

ADHD

Autismespekter

Utvikling og livsmestring

Motorikk

Språk (reseptivt/ekspressivt)

Tiltak

Psykososiale hjelpetiltak

Tiltak rettet mot gravide og barselkvinner

Alternativ behandling

Kosttilskudd og ernæring

Aldersgruppe

Sped- og småbarn (0-2 år)

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