Melatonin i behandling av søvnproblemer hos barn med nevroutviklingsforstyrrelser: Systematisk oversikt og metaanalyse

Melatonin for the management of sleep problems in children with neurodevelopmental disorders: A systematic review and meta-analysis

Forfattere
Abdelgadir, I. S. Gordon, M. A. Akobeng, A. K.
Årstall
2018
Tidsskrift
Archives of Disease in Childhood
Volum
103
Sider
1155-1162
Importance Children with neurodevelopmental disorders have a higher prevalence of sleep disturbances. Currently there is variation in the use of melatonin; hence, an up-to-date systematic review is indicated to summarise the current available evidence. Objective To determine the efficacy and safety of melatonin as therapy for sleep problems in children with neurodevelopmental disorders. Data sources and study selections PubMed, Embase, the Cumulative Index to Nursing and Allied Health Literature and the Cochrane Central Register of Controlled Trials were searched from inception up to January 2018. Two reviewers performed data assessment and extraction. We assessed randomised controlled trials that compared melatonin with placebo or other intervention for the management of sleep disorders in children (<18 years) with neurodevelopmental disorders. Data extraction and synthesis We identified 3262 citations and included 13 studies in this meta-analysis. Main outcomes Main outcomes included total sleep time, sleep onset latency, frequency of nocturnal awakenings and adverse events. Results Thirteen randomised controlled trials (n=682) met the inclusion criteria. A meta-analysis of nine studies (n=541) showed that melatonin significantly improved total sleep time compared with placebo (mean difference (MD)=48.26 min, 95% CI 36.78 to 59.73, I 2 =31%). In 11 studies (n=581), sleep onset latency improved significantly with melatonin use (MD=-28.97, 95% CI -39.78 to -18.17). No difference was noted in the frequency of nocturnal awakenings (MD=-0.49, 95% CI -1.71 to 0.73). No medication-related serious adverse event was reported. Conclusion Melatonin appeared safe and effective in improving sleep in the studied children. The overall quality of the evidence is limited due to heterogeneity and inconsistency. Further research is needed. Copyright © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Oversett med Google Translate
-
Tiltaksnivå

Tidlig innsats

Behandling og hjelpetiltak

Tema

Psykiske vansker og lidelser

Andre problemer

Søvn (inkl. søvnforstyrrelser)

Biologiske risikofaktorer, sykdommer og symptomer

Psykisk/fysisk funksjonsnedsettelse

Tiltak

Alternativ behandling

Kosttilskudd og ernæring

Aldersgruppe

Sped- og småbarn (0-2 år)

Barn i førskolealder (3-5 år)

Barn i skolealder (6-12 år)

Ungdom (13-18 år)

Mer informasjon
Leter du etter mer informasjon om temaet? Trykk på lenkene nedenfor for å søke i PsykTestBarn og Håndboka for barn og unges psykiske helse.