Efficacy of psychosocial interventions for young offspring of parents with a serious physical or mental illness: Systematic review and meta-analysis

Efficacy of psychosocial interventions for young offspring of parents with a serious physical or mental illness: Systematic review and meta-analysis

Authors
Landi, G. Pakenham, K. I. Bao, Z. Cattivelli, R. Crocetti, E. Tossani, E. Grandi, S.
Year
2025
Journal
Clinical Psychology Review
Volume
118
Pages
102569
Serious parental physical or mental illness significantly increases the risk of adverse adjustment outcomes in adolescents and young adults. This systematic review and meta-analysis evaluates the efficacy of psychosocial interventions targeting this vulnerable group. Eligible randomized control trials (RCTs) were searched through the Medline, Web of Science, PsycINFO, PsycArticles, Cinahl, and ProQuest Dissertation and Theses databases. Young offspring outcomes included: psychological (including internalizing and externalizing problems), positive, and interpersonal adjustment. Thirty-one manuscripts reporting on twenty-seven independent RCTs, including 3590 adolescent and young adult offspring, met eligibility criteria. Most of the studies targeted adolescents with a mean age within +/-1 SD of 12.17-16.33 years, with only one study directly targeting young adults. Three-quarters of studies included parental mental illness, and the remaining parental physical illness. Results highlighted a small post-intervention effect for psychological adjustment (d = 0.17,[0.05,0.29], p = .006), maintained at short-term (3-12 months) follow-up (d = 0.33 [0.12,0.54], p = .002), but not at long-term (15 months or longer) follow-up (d = -0.00 [-0.19,0.19], p = .98). A similar pattern emerged for internalizing problems, while for externalizing problems, no significant post-intervention effect was detected. Results also showed a small post-intervention effect for positive adjustment (d = 0.36,[0.10,0.61], p = .006), which increased to a medium effect at short-term follow-up (d = 0.62,[0.15,1.09], p = .010). Post-intervention effects were not present for interpersonal adjustment. Intervention duration moderated effects on post-intervention outcomes, while intervention setting and gender balance moderated outcomes at follow-ups. Psychosocial interventions for young offspring of parents with serious illnesses appear effective in improving psychological and positive outcomes with small-to-moderate effects at post-intervention and short-term follow-up.

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Type of intervention

Treatment and Child Welfare Interventions

Topic

Behavior Problems

Externalizing Behaviors / Challenging Behaviors

Emotional Problems

Depression and Depressed Mood

Anxiety Problems

Anxiety and Anxiousness

Parenting Skills

Children of parents with serious mental or physical illness

Development and Life Coping Skills

Well-being

Intervention

Psychological Treatments

Family Therapy

Parent Guidance / Therapy

Cognitive Behavioral Therapy, Behavioral Therapy and Cognitive Therapy

Mindfulness

Psychodynamic/Interpersonal Therapy

Psychoeducational Interventions

The organization of interventions

Group Interventions

Age group

School Aged Children (6-12 years)

Adolescents (13-18 years)

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