Background and Objective: Depression is a long-term mood condition that produces sorrow, loss of pleasure and interest, frequently with cognitive impairment. The incidence and lifetime prevalence of depression in children and adolescents are rising across all patient categories. According to statistics, 20% of teens experience significant depression. This study conducted a comprehensive review to analyse the impact of combining fluoxetine with cognitive behaviour therapy in the treatment of non-suicidal self-injury in adolescents.
Materials and Methods: The Cochrane Library, PubMed, Embase and Web of Science were searched for controlled trials of fluoxetine and cognitive behaviour therapy for depressed adolescents. Screening and extracting material for systematic review occurred between database inception and May, 2023.
Results: Seven trials included 893 participants. The systematic review found that the intervention group had a significantly higher rate of remission (OR: 1.11; 95% Cl: 1.03, 1.20; p<0.01) than the untreated group. The two groups of patients had similar rates of recurrence, self-injury adverse events and overall adverse events (OR: 0.96; 95% CI: 0.57, 1.61; p = 0.868).
Conclusion: This study demonstrated the stability and reliability of fluoxetine and cognitive behaviour therapy for depressed teenagers. The findings showed that fluoxetine and cognitive behaviour therapy may help depressed teenagers remit.
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