Effekten av jern-tilskudd for ikke-anemiske gravide kvinner, sped- og småbarn på mental prestasjonsevne og psykomotorisk utvikling hos barn: en systematisk oversikt over randomiserte, kontrollerte forsøk

Effects of iron supplementation in nonanemic pregnant women, infants, and young children on the mental performance and psychomotor development of children: a systematic review of randomized controlled trials

Forfattere
Szajewska, H. Ruszczynski, M. Chmielewska, A.
Årstall
2010
Tidsskrift
American Journal of Clinical Nutrition
Volum
91
Sider
1684-90
BACKGROUND: Uncertainty exists regarding the effects of iron supplementation on neurodevelopmental outcomes in the absence of anemia. OBJECTIVE: Our objective was to evaluate the effects of iron supplementation in nonanemic pregnant women and in nonanemic healthy children aged <3 y on the mental performance and psychomotor development of children. DESIGN: In this systematic review, MEDLINE, EMBASE, and The Cochrane Library were searched through December 2009 for randomized controlled trials (RCTs). RESULTS: None of 5 RCTs individually showed a beneficial effect of iron supplementation during early life on the Mental Developmental Index of the Bayley Scales of Infant Development at different ages throughout the first 18 mo. Meta-analysis of 3 RCTs (n = 561) showed that, compared with placebo, supplementation with iron had no significant effect on children's Mental Developmental Index at approximately 12 mo of age (weighted mean difference: 1.66; 95% CI: -0.14, 3.47). Three of 5 RCTs showed a beneficial effect of iron supplementation on the Psychomotor Development Index at some time points, whereas 2 did not. Meta-analysis of 3 RCTs (n = 561) showed significant improvement on the Psychomotor Development Index at approximately 12 mo of age in the iron-supplemented group compared with the control group (weighted mean difference: 4.21; 95% CI: 2.31, 6.12). Two RCTs showed no effect of iron supplementation on behavior. Neither of the 2 RCTs that addressed the influence of prenatal iron supplementation showed an effect of iron on either the intelligence quotient or behavioral status of the children. CONCLUSION: Limited available evidence suggests that iron supplementation in infants may positively influence children's psychomotor development, whereas it does not seem to alter their mental development or behavior.

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Tiltaksnivå

Forebyggende og helsefremmende tiltak

Tema

Utvikling og livsmestring

Kognisjon (hukommelse, oppmerksomhet, eksekutive funksjoner)

Biologiske risikofaktorer, sykdommer og symptomer

Gravide (inkl. tenåringsmødre)

Tiltak

Psykososiale hjelpetiltak

Tiltak rettet mot gravide og barselkvinner

Alternativ behandling

Kosttilskudd og ernæring

Aldersgruppe

Sped- og småbarn (0-2 år)

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