Effekt av jod-tilskudd i graviditeten på barns utvikling og andre kliniske utfall: en systematisk oversikt over randomiserte, kontrollerte forsøk

Effect of iodine supplementation in pregnancy on child development and other clinical outcomes: a systematic review of randomized controlled trials

Authors
Zhou, S. J. Anderson, A. J. Gibson, R. A. Makrides, M.
Year
2013
Journal
American Journal of Clinical Nutrition
Volume
98
Pages
1241-54
BACKGROUND: Routine iodine supplementation during pregnancy is recommended by leading health authorities worldwide, even in countries where the iodine status of the population is sufficient. OBJECTIVES: We evaluated the efficacy and safety of iodine supplementation during pregnancy or the periconceptional period on the development and growth of children. Secondary outcomes included pregnancy outcome and thyroid function. DESIGN: A systematic review of randomized controlled trials (RCTs) was conducted. PUBMED, MEDLINE, EMBASE, CINAHL, PsycINFO, and Cochrane Central Register of Controlled Trials databases were searched to identify relevant RCTs. RESULTS: Fourteen publications that involved 8 trials met the inclusion criteria. Only 2 included trials reported the growth and development of children and clinical outcomes. Iodine supplementation during pregnancy or the periconceptional period in regions of severe iodine deficiency reduced risk of cretinism, but there were no improvements in childhood intelligence, gross development, growth, or pregnancy outcomes, although there was an improvement in some motor functions. None of the remaining 6 RCTs conducted in regions of mild to moderate iodine deficiency reported childhood development or growth or pregnancy outcomes. Effects of iodine supplementation on the thyroid function of mothers and their children were inconsistent. CONCLUSIONS: In this review, we highlight a lack of quality evidence of the effect of prenatal or periconceptional iodine supplementation on growth and cognitive function of children. Although contemporary RCTs of iodine supplementation with outcomes addressing childhood development are indicated, conduct of such RCTs may not be feasible in populations where iodine supplementation in pregnancy is widely practiced.

Oversett med Google Translate
-
Type of intervention

Preventive- and Promotive Health Interventions

Topic

Development and Life Coping Skills

Cognition

Motor development

Biological Risk Factors, Diseases and Symptoms

Pregnancy

Intervention

Psychosocial Treatments

Interventions for Pregnant Women and Postpartum Women

Alternative Treatment

Nutritional Supplements and Nutrition

Age group

Infants and Toddlers (0-2 years)

More information
Looking for more information on this topic? Click on the links below to search PsykTestBarn and Håndboka