Cognitive behavior therapy for depression in people with epilepsy: A systematic review and meta-analysis

Cognitive behavior therapy for depression in people with epilepsy: A systematic review and meta-analysis

Li, D. X. Song, Y. Q. Zhang, S. Y. Qiu, J. Zhang, R. Wu, J. Y. Wu, Z. Y. Wei, J. W. Xiang, X. F. Zhang, Y. Yu, L. D. Wang, H. H. Niu, P. Fan, C. Li, X. M.
Epilepsy & Behavior
Background: Cognitive behavioral therapy (CBT) is the recommended treatment for depression in patients with epilepsy (PWE). However, there are no studies that calculate the effect size of CBT on depression and quality of life (QoL) in PWE. Methods: We searched seven electronic databases (PubMed, Web of Science, Embase, Cochrane Library, Clinical Trials, Ovid Medline, and PsycINFO). We included 13 studies examining CBT for depression in PWE and calculated its effect size. Results: A total of 13 studies met the criteria. After treatment, CBT improves depression in PWE (g = 0.36, 95%CI: 0.18 to 0.54, I2 = 50%), and the efficacy maintains during follow-up (g = 0.47, 95%CI: 0.04 to 0.89, I2 = 80%). Subgroup analysis has shown that individual CBT (g = 0.47, 95%CI: 0.20 to 0.73, I2 = 0%) had a greater effect size than group CBT (g = 0.30, 95%CI: 0.07 to 0.53, I2 = 62%) in the treatment of depression. Likewise, CBT has a positive effect on the QoL improvement of PWE (g = 0.34, 95%CI: 0.11 to 0.57, I2 = 64%). In controlling seizures, CBT did not differ from the control group (g =-0.06, 95%CI:-0.32 to 0.19, I2 = 0%). Conclusions: Cognitive behavioral therapy interventions were effective in improving depression and QoL in PWE, but not effective in controlling seizures. The efficacy of CBT interventions targeting seizure con-trol seems to be uncertain. (c) 2022 Elsevier Inc. All rights reserved.

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Type of intervention

Early Intervention

Treatment and Child Welfare Interventions


Mental Health Problems and Disorders

Emotional Problems

Depression and Depressed Mood

Biological Risk Factors, Diseases and Symptoms

Somatic Disease


Psychological Treatments

Cognitive Behavioral Therapy, Behavioral Therapy and Cognitive Therapy

Age group

Adolescents (13-18 years)

Age not specified

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