Aripiprazol: en oversikt over bruk i behandlingen av irritabilitet assosiert med autismelidelser hos pasienter i alderen 6 - 17

Aripiprazole: a review of its use in the treatment of irritability associated with autistic disorder patients aged 6-17

Forfattere
Douglas-Hall, P. Curran, S. Bird, V. Taylor, D.
Årstall
2011
Tidsskrift
Journal of Central Nervous System Disease
Volum
3
Sider
143-53
A systematic review and meta-analysis were performed examining the efficacy of aripiprazole for the treatment of irritability associated with autistic disorder in children and adolescents. Aripiprazole was found to be more effective in reducing irritability compared with placebo at 8 weeks, SMD -0.64 [-0.90 to -0.39, P < 0.00001] as determined by the Aberrant Behaviour Checklist irritability subscale (ABC-I). Pooled data from two eight week trials show that sedation is the most commonly reported adverse event. Statistically significant weight gain was also associated with aripiprazole, but there was a decrease in serum prolactin. Most adverse effects were deemed to be mild to moderate in severity. Four open trials and three case series all show support for aripiprazole in reducing the behavioural symptoms of autism. Long-term studies are required to determine the efficacy and safety of aripiprazole in autistic disorder in children.

Oversett med Google Translate
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Tiltaksnivå

Behandling og hjelpetiltak

Tema

Psykiske vansker og lidelser

Autismespekter

Tiltak

Medikamentell behandling

Antipsykotisk medisin

Aldersgruppe

Barn i skolealder (6-12 år)

Ungdom (13-18 år)

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