Antiepilektika ved autismespekterforstyrrelse: systematisk oversikt og metaanalyse

Antiepileptic Medications in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

Forfattere
Hirota, T. Veenstra-VanderWeele, J. Hollander, E. Kishi, T.
Årstall
2014
Tidsskrift
Journal of Autism and Developmental Disorders
Volum
44
Sider
948-957
Electroencephalogram-recorded epileptiform activity is common in children with autism spectrum disorder (ASD), even without clinical seizures. A systematic literature search identified 7 randomized, placebo-controlled trials of antiepileptic drugs (AEDs) in ASD (total n = 171), including three of valproate, and one each of lamotrigine, levetiracetam, and topiramate. Meta-analysis revealed no significant difference between medication and placebo in four studies targeting irritability/agitation and three studies investigating global improvement, although limitations include lack of power and different medications with diverse actions. Across all seven studies, there was no significant difference in discontinuation rate between two groups. AEDs do not appear to have a large effect size to treat behavioral symptoms in ASD, but further research is needed, particularly in the subgroup of patients with epileptiform abnormalities.

Oversett med Google Translate
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Tiltaksnivå

Behandling og hjelpetiltak

Tema

Psykiske vansker og lidelser

Autismespekter

Tiltak

Medikamentell behandling

20.60 Epilepsimedisin

Aldersgruppe

Barn i førskolealder (3-5 år)

Barn i skolealder (6-12 år)

Uklar aldersgruppe

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