A review of Cochrane reviews on pharmacological treatment for attention deficit hyperactivity disorder

A review of Cochrane reviews on pharmacological treatment for attention deficit hyperactivity disorder

Forfattere
Santos, G. M. Santos, E. M. Mendes, G. D. Fragoso, Y. D. Souza, M. R. Martimbianco, A. L. C.
Årstall
2021
Tidsskrift
Dementia & Neuropsychologia
Volum
15
Sider
421-427
Attention deficit hyperactivity disorder (ADHD) is one of the most frequent childhood psychiatric problems. Objective: The objective of this study was to identify, synthesize the results, and critically evaluate all Cochrane systematic reviews (SRs) on the pharmacological interventions for children and adolescents (up to age 18) diagnosed with ADHD. Methods: The search was performed in the Cochrane Database of Systematic Reviews (via Wiley) in July 2020. Results: The search strategy resulted in four SRs of high methodological quality, analyzing 51 randomized clinical trials (9,013 participants). Compared to placebo, treatment with tricyclic antidepressants (TCAs) (desipramine), amphetamine, and methylphenidate showed improvement in symptoms such as difficulty concentrating, impulsivity, and hyperactivity in the short term (up to 6 months). There was an increase in the occurrence of adverse events, such as reduced appetite, difficulty sleeping, and abdominal pain. Insufficient evidence was found to support the effects of supplementation with polyunsaturated fatty acids. Conclusions: The use of TCAs, amphetamine, and methylphenidate in children and adolescents with ADHD seems to present positive effects and higher rates of minor adverse events when compared to placebo.

Oversett med Google Translate
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Tiltaksnivå

Behandling og hjelpetiltak

Tema

Psykiske vansker og lidelser

ADHD

Tiltak

Medikamentell behandling

Antidepressiva

Stimulerende midler

Alternativ behandling

Kosttilskudd og ernæring

Aldersgruppe

Sped- og småbarn (0-2 år)

Barn i førskolealder (3-5 år)

Barn i skolealder (6-12 år)

Ungdom (13-18 år)

Egenskaper

Cochrane-oversikter

Oversikter over oversikter

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